![]() ![]() The researchers analyzed these data using machine learning, seeking attributes of the mice that could best explain the animals' sizeable inter-individual differences in running performance. They then measured the amount of daily voluntary wheel running the animals did, as well as their endurance. They recorded the genome sequences, gut bacterial species, bloodstream metabolites, and other data for genetically diverse mice. Thaiss and colleagues set up the study to search broadly for factors that determine exercise performance. "If we can confirm the presence of a similar pathway in humans, it could offer an effective way to boost people's levels of exercise to improve public health generally," said study senior author Christoph Thaiss, PhD, an assistant professor of Microbiology at Penn Medicine. ![]() The researchers traced this effect to small molecules called metabolites that the bacteria produce - metabolites that stimulate sensory nerves in the gut to enhance activity in a motivation-controlling brain region during exercise. ![]() ![]() In the study, the researchers found that differences in running performance within a large group of lab mice were largely attributable to the presence of certain gut bacterial species in the higher-performing animals. ![]()
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